Ilya Pharma AB

Developing the next-generation
biological drugs for treating wounds
in skin and mucosa

News

2020-05-13

Resuming recruitment to the ongoing clinical trial - final cohorts

2020-04-20

In press

2020-03-30

Ilya Pharma receives Bio-X grant to complete preclinical work for novel IBD chemokine-based gene therapy candidates

2020-02-01

Ilya Pharmas technology explained in a nice conversation in - Discovery Matters

Pod cast Discovery matters, episode 13. Scratched knees, smelly yogurt, and speedy wound healing

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Ilya Pharma, a clinical stage Swedish company, is developing drug candidates from its own technology platform to PoC in clinical phase I and II.

Human therapeutic proteins are produced at the actual wound site by live lactic acid bacteria acting as mini-bioreactors. This provides a new and cost effective way to deliver biological drugs. The formulation is freezedried with good stability and the lactic acid bacteria are revived immediately prior to use by adding a small volume of buffer solution.

The drug candidates are classified as ATMP or gene therapies by the EMA and FDA and the project is fully compliant.

The innovation stems from cutting edge medical research in immunophysiology and applied microbiology at Uppsala University and the Swedish University of Agriculture. The treatments target the function of tissue-resident immune cells and the mechanism of accelerated healing in skin wounds was published in PNAS 2018.

Unmet clinical needs targeted by ILYA Pharma are treatment of post surgical wounds in special populations, problematic diabetic wounds, and indications in the gastrointestinal tract, such as inflammatory bowel disease.

For wound healing, we expect to deliver clinical value by providing cost efficient biological treatments substantially cheaper than traditional biologicals and with better efficacy than medical devices.

The company is currently running a first in human trial with the lead candidate ILP100, EudraCT No. 2019000680-24 and are planning the phase II program to be conducted under an IND.

Ilya Pharma is today financed by a mix of grants and private funding. The company received a H2020 SME Instrument phase II grant 2018 of 3M Euro. The company is currently raising a Series A for the continued clinical development in phase II from suitable investors and potential partners with proven track record in cell- and gene therapy and biologics.

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	Evelina Vågesjö, CEO Co-founder, PhD in physiology, MBA focus Finance and MnA. Developed methods to steer immune cell functions and delineated a new mechanism of action during in tissue regeneration. Have managed the project from initial idea to clinical proof of concept and scaling of the company.
	Mia Phillipson, Co-founder Professor in Physiology at Uppsala University. Internationally recognized expert in physiology and immunology. Multiple discoveries in Professor Phillipson’s lab have led to clinical initiatives.
	Peter Frank, COO Background in the industry of more than 15 years working with development of biologics. Previous recent positions at GE Healthcare and Galderma as project manager, responsible for CMC, taking a compound through the development and critical phases from clinical Phase I to Phase III and setting up manufacturing.
	Ingemar Kihlström, Chairman of the Board Extensive experience in finance and drug development at multiple firms including Astra Zeneca and Pharmacia. PhD in physiology/toxicology from Uppsala University. Experience from serving at the board of >30 companies often as chairman. Co-founder of life science companies and managed several licensing deals and IPOs in the industry.
	Andreas Fasth, Head of Clinical Developments Background in research in translational immunology at the Rheumatology Unit at Karolinska Institutet, and more than ten years experience of work in Medical Affairs and Clinical Development in big Pharma companies, including MSD and Novartis.
	Lovisa Ringstad, Head of CMC PhD in Pharmacy. Background in biophysical chemistry with focus on formulation development and topical administration. More than ten years experience from project management in the Pharma industry and at research institutes (most recent at RISE).